Phenotypes associated with this allele

• Allele Symbol: Slco1b2^tm1Cdk
• Allele Name: targeted mutation 1, Curtis D Klaassen
• Allele ID: MGI:3785252
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slco1b2^tm1Cdk/Slco1b2^tm1Cdk	B6.129S1-Slco1b2^tm1Cdk	MGI:3785254
hm2	Slco1b2^tm1Cdk/Slco1b2^tm1Cdk	involves: 129S1/Sv * C57BL/6	MGI:3785253

Genotype
MGI:3785254

hm1

• Allelic Composition: Slco1b2^tm1Cdk/Slco1b2^tm1Cdk
• Genetic Background: B6.129S1-Slco1b2^tm1Cdk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:133919 )

• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection

homeostasis/metabolism

increased circulating bilirubin level ( J:133919 )

• increased about 2.5-fold in females, mostly as a result of an increase in conjugated bilirubin

increased circulating cholesterol level ( J:133919 )

• increased by about 30% in null males compared to wild-type males

abnormal circulating mineral level ( J:133919 )

increased circulating sodium level ( J:133919 )

• slight but statistically significant increase in females

abnormal circulating protein level ( J:133919 )

increased circulating alanine transaminase level ( J:133919 )

• slight but statistically significant increase in females

decreased circulating amylase level ( J:133919 )

• slight but statistically significant decrease in females

abnormal circulating serum albumin level ( J:133919 )

• slight increase in both genders

increased circulating total protein level ( J:133919 )

• slight increase in both genders

increased circulating chloride level ( J:133919 )

• slight but statistically significant increase in females

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:133919 )

• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection

decreased physiological sensitivity to xenobiotic ( J:133919 )

• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice

liver/biliary system

abnormal liver physiology ( J:133919 )

• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice

Genotype
MGI:3785253

hm2

• Allelic Composition: Slco1b2^tm1Cdk/Slco1b2^tm1Cdk
• Genetic Background: involves: 129S1/Sv * C57BL/6

liver/biliary system

abnormal liver physiology ( J:133919 )

• lack hepatic uptake of phalloidin and are completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg)

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:133919 )

• completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg)

• however, sensitivity to alpha-amanitin-induced hepatotoxicity is similar to controls

abnormal xenobiotic pharmacokinetics ( J:133919 )

• lack hepatic uptake of phalloidin