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Gene trapped Allele Detail
Symbol: Vangl1Gt(XL802)Byg
Name: vang-like 1 (van gogh, Drosophila); gene trap XL802, BayGenomics
MGI ID: MGI:3778822
Synonyms: Vangl1gt
Gene: Vangl1  Location: Chr3:102156701-102204693 bp, - strand  Genetic Position: Chr3, 44.3 cM
Vangl1Gt(XL802)Byg/Vangl1+ Vangl2Lp/Vangl2+ and Vangl2Lp/Vangl2Lp embryos exhibit aberrant right subclavian artery

Show the 4 phenotype image(s) involving this allele.

Mutant Cell Line:  XL802 (BayGenomics)
Germline Transmission:  Earliest citation of germline transmission: J:132697
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
Mutation detailsA pGT0Lxf beta-geo gene-trap vector inserted into intron 3 237 nucleotides downstream of the exon 3 donor splice-site. RT-PCR confirmed the expression of only mutant transcript in all but 1 homozygote. Only very low expression of normal transcript was detected in this homozygote. (J:132697)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vangl1 Mutation:  63 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

Original:  J:132697 Torban E, et al., Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3449-54
All:  6 reference(s)

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MGI 5.21
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