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Targeted Allele Detail
Symbol: Nfkbidtm1Clay
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta; targeted mutation 1, Linda K Clayton
MGI ID: MGI:3777661
Synonyms: IkappaBNS-
Gene: Nfkbid  Location: Chr7:30421732-30428746 bp, + strand  Genetic Position: Chr7, 17.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:132071
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 4.8 kb region of the gene containing exons 1 through 5 and most of exon 6 was replaced by a neomycin resistance cassette. No gene expression is detected in microarray analysis of homozygote T cells. (J:132071)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nfkbid Mutation:  16 strains or lines available
Original:  J:132071 Touma M, et al., Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 1;179(3):1681-92
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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