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Nfkbidtm1Clay
Targeted Allele Detail
Nomenclature
Symbol: Nfkbidtm1Clay
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta; targeted mutation 1, Linda K Clayton
MGI ID: MGI:3777661
Synonyms: IkappaBNS-
Gene: Nfkbid  Location: Chr7:30421732-30428746 bp, + strand  Genetic Position: Chr7, 17.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132071
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 4.8 kb region of the gene containing exons 1 through 5 and most of exon 6 was replaced by a neomycin resistance cassette. No gene expression is detected in microarray analysis of homozygote T cells. (J:132071)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nfkbid Mutation:  12 strains or lines available
References
Original:  J:132071 Touma M, et al., Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 1;179(3):1681-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory