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Targeted Allele Detail
Symbol: Hdac6tm1.1Pmt
Name: histone deacetylase 6; targeted mutation 1.1, Patrick Matthias
MGI ID: MGI:3776868
Gene: Hdac6  Location: ChrX:7930120-7947889 bp, - strand  Genetic Position: ChrX, 3.58 cM
Germline Transmission:  Earliest citation of germline transmission: J:132629
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 8, 9 and 10 were removed by transient cre expression in ES cells. The absence of protein product was confirmed by western blot analysis on brain, heart, kidney, liver, spleen and testis extracts. (J:132629)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac6 Mutation:  8 strains or lines available
Original:  J:125219 Boyault C, et al., HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007 Sep 1;21(17):2172-81
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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