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Hdac6tm1.1Pmt
Targeted Allele Detail
Nomenclature
Symbol: Hdac6tm1.1Pmt
Name: histone deacetylase 6; targeted mutation 1.1, Patrick Matthias
MGI ID: MGI:3776868
Gene: Hdac6  Location: ChrX:7930120-7947889 bp, - strand  Genetic Position: ChrX, 3.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132629
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 8, 9 and 10 were removed by transient cre expression in ES cells. The absence of protein product was confirmed by western blot analysis on brain, heart, kidney, liver, spleen and testis extracts. (J:132629)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac6 Mutation:  4 strains or lines available
References
Original:  J:125219 Boyault C, et al., HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007 Sep 1;21(17):2172-81
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory