Card11^tm1Xav
Targeted Allele Detail

Summary

• Symbol: Card11^tm1Xav
• Name: caspase recruitment domain family, member 11; targeted mutation 1, Ramnik Xavier
• MGI ID: MGI:3776490
• Synonyms: CARMA1^-
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^tm1Xav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132226
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Frt-flanked zeomycin/neomycin resistance cassette replaced exon 4 and parts of exons 3 and 5. Genomic PCR and FISH analysis confirmed correct targeting of the gene. The mice are predicted to have a null phenotype. (J:132226)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 58 strains or lines available

References

• Original: J:132226 Medoff BD, et al., CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma. J Immunol. 2006 Jun 15;176(12):7272-7
• All: 2 reference(s)