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Gt(ROSA)26Sortm1Uzs
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1Uzs
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ursula Zimber-Strobl
MGI ID: MGI:3776037
Synonyms: CD40/LMP1flSTOP, Gt(ROSA)26Sortm1(CD40/Lmp1)Uzs
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130768
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change)
Mutation:    Insertion
 
Mutation detailscDNA encoding the first 214 amino acids of Cd40 were fused to the cDNA encoding the Epstein-Barr latent membrane protein 1 (LMP1) and inserted into a modified ROSA locus that contained a floxed stop, non-expressing RFP and frt-flanked neo cassette. The fusion protein is only expressed following cre-mediated recombination to remove the stop cassette. (J:130768)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
References
Original:  J:130768 Rastelli J, et al., LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. Blood. 2008 Feb 1;111(3):1448-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory