Tg(Col6a1-cre)1Gkl
Transgene Detail

Summary

• Symbol: Tg(Col6a1-cre)1Gkl
• Name: transgene insertion 1, George Kollias
• MGI ID: MGI:3775430
• Synonyms: ColVI-Cre
• Transgene: Tg(Col6a1-cre)1Gkl Location: unknown
• Alliance: Tg(Col6a1-cre)1Gkl page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Col6a1-cre)1Gkl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Col6a1

• Mutation details: 6.2 kb of sequence containing the upstream enhancer/promoter and 1.3kb downstream sequence containing exon 1 and part of exon 2 were used to drive Cre expression. Transgene expression was observed in numerous mesenchymal cells including fibroblasts, articular chondrocytes and myoblasts, skin keratinocytes, and underneath the epithelial layer of the gut. (J:131930)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col6a1 (species not specified) Summary of all recombinase alleles driven by Col6a1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131930 Armaka M, et al., Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med. 2008 Feb 18;205(2):331-7
• All: 19 reference(s)