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Ldhctm1Erg
Targeted Allele Detail
Summary
Symbol: Ldhctm1Erg
Name: lactate dehydrogenase C; targeted mutation 1, Erwin Goldberg
MGI ID: MGI:3775042
Synonyms: testis Ldh knockout
Gene: Ldhc  Location: Chr7:46510687-46527571 bp, + strand  Genetic Position: Chr7, 30.6 cM
Alliance: Ldhctm1Erg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132072
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was placed upstream of exon 3 replacing a 31 bp fragment and a floxed neo cassette was placed downstream of exon 3 replacing a 71 bp fragment. In vivo Cre mediated recombination removed the entire floxed region including exon 3. Western blot and immunohistochemical analysis confirmed the absence of protein expression in testes. (J:132072)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ldhc Mutation:  14 strains or lines available
References
Original:  J:132072 Odet F, et al., Expression of the gene for Lactate Dehydrogenase C: Ldhc is required for male fertility. Biol Reprod. 2008;79(1):26-34
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory