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Transgene Detail
Symbol: Tg(ACTA1-SMN)63Ahmb
Name: transgene insertion 63, Arthur H M Burghes
MGI ID: MGI:3774939
Synonyms: HSA63-SMN, HSA69-SMN
Transgene: Tg(ACTA1-SMN)63Ahmb  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(ACTA1-SMN)63Ahmb expresses 1 gene
Mutation detailshe HSA-SMN transgene was designed with the human alpha-skeletal actin (HSA or ACTA1) promoter region, splice acceptor site from the SV40 VP1 intron, full-length human SMN cDNA (containing exons 1-8), and two SV40 polyA signals. Mice from founder line 63 (HSA63-SMN) were found to have 5 copies of the transgene. (J:97103, J:131663)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:131663 Gavrilina TO, et al., Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle specific SMN expression has no phenotypic effect. Hum Mol Genet. 2008 Jan 4;
All:  3 reference(s)

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MGI 6.04
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