Analysis Tools
mortality/aging
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• double mutants survive an average of 6.6 days, with some living past 15 days, representing a slight but significant increase compared to Smn1tm1Msd homozygotes
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Allele Symbol Allele Name Allele ID |
Tg(ACTA1-SMN)63Ahmb transgene insertion 63, Arthur H M Burghes MGI:3774939 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double mutants survive an average of 6.6 days, with some living past 15 days, representing a slight but significant increase compared to Smn1tm1Msd homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double mutants survive an average of 160 days, with some living up to a year
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• muscle fiber distribution is different from normal muscle; mice have a greater number of smaller diameter fibers relative to controls
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• tail becomes necrotic by 21 days of age, resulting in tail being very short
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• tail becomes necrotic by 21 days of age, resulting in tail being very short
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• expression of the transgene does not adversely affect the phenotype relative to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• expression of the transgene does not adversely affect the phenotype relative to wild-type
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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