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Ptprjtm1.2Weis
Targeted Allele Detail
Nomenclature
Symbol: Ptprjtm1.2Weis
Name: protein tyrosine phosphatase, receptor type, J; targeted mutation 1.2, Arthur Weiss
MGI ID: MGI:3774766
Synonyms: CD148-, PtprjTM-
Gene: Ptprj  Location: Chr2:90429754-90580647 bp, - strand  Genetic Position: Chr2, 50.19 cM, cytoband E1-2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131736
Parent Cell Line:  E14.1TG3B1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was designed to introduce a loxP-flanked neomycin-resistance cassette in reverse transcriptional orientation to intron 17 and an additional loxP site to intron 18. Exon 18 encodes the transmembrane domain of the gene (also called CD148). Targeted animals were bred with BALB/c-background CMV-Cre transgenic female mice to delete the neomycin cassette and exon 18. Transmembrane domain-deleted mice were obtained and characterized. CD148 protein is not detected on any cells of hematopoietic origin by immunoblotting or flow cytometry. (J:131736)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptprj Mutation:  7 strains or lines available
References
Original:  J:131736 Zhu JW, et al., Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity. 2008 Feb;28(2):183-96
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory