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Sh2d1atm2Vei
Targeted Allele Detail
Nomenclature
Symbol: Sh2d1atm2Vei
Name: SH2 domain containing 1A; targeted mutation 2, Andre Veillette
MGI ID: MGI:3774546
Synonyms: sapfl
Gene: Sh2d1a  Location: ChrX:42502565-42522097 bp, + strand  Genetic Position: ChrX, 23.2 cM, cytoband A5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131618
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. The neo cassette ws removed by flp-mediated recombination. (J:131618)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d1a Mutation:  7 strains or lines available
References
Original:  J:131618 Veillette A, et al., SAP expression in T cells, not in B cells, is required for humoral immunity. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1273-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory