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Targeted Allele Detail
Symbol: Npeppstm1Klr
Name: aminopeptidase puromycin sensitive; targeted mutation 1, Kenneth L Rock
MGI ID: MGI:3774016
Synonyms: PSA-
Gene: Npepps  Location: Chr11:97205842-97280638 bp, - strand  Genetic Position: Chr11, 60.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:131502
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129 x C57BL/6)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 4 through 9 were replaced with a lacZ-neo cassette. This deletion includes half of the enzymatic core encoded in exon 9 and 10. The presence of a truncated transcript lacking exons 10 and 11 was confirmed by RT-PCR analysis. (J:131502)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npepps Mutation:  57 strains or lines available
Original:  J:131502 Towne CF, et al., Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. J Immunol. 2008 Feb 1;180(3):1704-12
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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