About   Help   FAQ
Npeppstm1Klr
Targeted Allele Detail
Nomenclature
Symbol: Npeppstm1Klr
Name: aminopeptidase puromycin sensitive; targeted mutation 1, Kenneth L Rock
MGI ID: MGI:3774016
Synonyms: PSA-
Gene: Npepps  Location: Chr11:97205842-97280638 bp, - strand  Genetic Position: Chr11, 60.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131502
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129 x C57BL/6)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 through 9 were replaced with a lacZ-neo cassette. This deletion includes half of the enzymatic core encoded in exon 9 and 10. The presence of a truncated transcript lacking exons 10 and 11 was confirmed by RT-PCR analysis. (J:131502)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npepps Mutation:  93 strains or lines available
References
Original:  J:131502 Towne CF, et al., Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. J Immunol. 2008 Feb 1;180(3):1704-12
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory