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Ednratm2.1Hku
Targeted Allele Detail
Nomenclature
Symbol: Ednratm2.1Hku
Name: endothelin receptor type A; targeted mutation 2.1, Hiroki Kurihara
MGI ID: MGI:3773698
Synonyms: EdnralacZ, EdnralacZ1FRT
Gene: Ednra  Location: Chr8:77663029-77724452 bp, - strand  Genetic Position: Chr8, 36.63 cM, cytoband C2
Comparison of craniofacial skeletons among E15.5 Ednratm2.1Hku/Ednratm2.1Hku (A), wild-type (B) and Ednratm6(Edn1)Hku/Ednra+ (C) mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131382
Parent Cell Line:  ATOM1 (ES Cell)
Strain of Origin:  (C57BL/6 x 129)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailspCAGGS-FLPe was microinjected into fertilized eggs obtained from ICR females crossed to Ednratm2Hku/+ male mice. Transient expression of flp recombinase results in the removal of the puromycin resistance cassette. Expression of the lacZ gene was confirmed by beta-galactosidase assay. (J:131382)
Recombinase-mediated cassette exchange to generate the first-step targeted (Ednratm1Hku), lacZ-knocked-in (Ednratm2.1Hku), Edn1-knocked-in (Ednratm6(Edn1)Hku), and Hand2-knocked-in (Ednratm7(Hand2)Hku) alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 33 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ednra Mutation:  7 strains or lines available
References
Original:  J:131382 Sato T, et al., Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development. 2008 Feb;135(4):755-65
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory