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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ednratm2.1Hku
targeted mutation 2.1, Hiroki Kurihara
MGI:3773698
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ednratm2.1Hku/Ednratm2.1Hku involves: 129 * C57BL/6 * ICR MGI:3796522
ht2
 		Ednratm1Hku/Ednratm2.1Hku involves: 129 * C57BL/6 * ICR MGI:3796524
ht3
 		Ednratm2.1Hku/Ednratm3(Ednrb)Hku involves: 129 * C57BL/6 * ICR MGI:3796526
ht4
 		Ednratm2.1Hku/Ednratm4(Ednra)Hku involves: 129 * C57BL/6 * ICR MGI:3796528
ht5
 		Ednratm2.1Hku/Ednratm5Hku involves: 129 * C57BL/6 * ICR MGI:4867386


Genotype
MGI:3796522
hm1
Allelic
Composition		 Ednratm2.1Hku/Ednratm2.1Hku
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednratm2.1Hku mutation (0 available); any Ednra mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Comparison of craniofacial skeletons among E15.5 Ednratm2.1Hku/Ednratm2.1Hku (A), wild-type (B) and Ednratm6(Edn1)Hku/Ednra+ (C) mice

mortality/aging

craniofacial
absent Meckel's cartilage ( J:224515 )
• loss of Meckel's cartillage
abnormal temporal bone morphology ( J:224515 )
• duplicated ala temporalis

skeleton
absent Meckel's cartilage ( J:224515 )
• loss of Meckel's cartillage
abnormal temporal bone morphology ( J:224515 )
• duplicated ala temporalis




Genotype
MGI:3796524
ht2
Allelic
Composition		 Ednratm1Hku/Ednratm2.1Hku
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednratm1Hku mutation (0 available); any Ednra mutation (34 available)
Ednratm2.1Hku mutation (0 available); any Ednra mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3796526
ht3
Allelic
Composition		 Ednratm2.1Hku/Ednratm3(Ednrb)Hku
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednratm2.1Hku mutation (0 available); any Ednra mutation (34 available)
Ednratm3(Ednrb)Hku mutation (0 available); any Ednra mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
abnormal craniofacial bone morphology ( J:131382 )
• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis
abnormal hyoid bone morphology ( J:131382 )
• hyoid in some mutants is fused only unilaterally to basisphenoid bone
• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn
abnormal mandible morphology ( J:131382 )
• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type
lower jaw to upper jaw transformation ( J:131382 )
• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5
• skeletal analysis shows duplication of upper jaw elements in lower jaw region

skeleton
abnormal craniofacial bone morphology ( J:131382 )
• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis
abnormal hyoid bone morphology ( J:131382 )
• hyoid in some mutants is fused only unilaterally to basisphenoid bone
• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn
abnormal mandible morphology ( J:131382 )
• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type
lower jaw to upper jaw transformation ( J:131382 )
• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5
• skeletal analysis shows duplication of upper jaw elements in lower jaw region




Genotype
MGI:3796528
ht4
Allelic
Composition		 Ednratm2.1Hku/Ednratm4(Ednra)Hku
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednratm2.1Hku mutation (0 available); any Ednra mutation (34 available)
Ednratm4(Ednra)Hku mutation (0 available); any Ednra mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:131382 )
N
• craniofacial skeletal morphology is indistinguishable from wild-type; incisive alveolar bone in distal mandibular region is relatively well-developed
• mice have relatively well-developed incisive alveolus




Genotype
MGI:4867386
ht5
Allelic
Composition		 Ednratm2.1Hku/Ednratm5Hku
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednratm2.1Hku mutation (0 available); any Ednra mutation (34 available)
Ednratm5Hku mutation (1 available); any Ednra mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:166932 )
• at E9.5, 40% of embryos have gourd-shaped hearts with disproportionate chamber sizes
abnormal heart development ( J:166932 )
• at E9.5 the number of proliferating cells is decreased in the compact and trabecular layers of the ventricular wall
abnormal heart ventricle morphology ( J:166932 )
• often have poorly developed ventricular walls at E9.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory