Phenotypes associated with this allele

• Allele Symbol: Ednra^tm2.1Hku
• Allele Name: targeted mutation 2.1, Hiroki Kurihara
• Allele ID: MGI:3773698
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ednra^tm2.1Hku/Ednra^tm2.1Hku	involves: 129 * C57BL/6 * ICR	MGI:3796522
ht2	Ednra^tm1Hku/Ednra^tm2.1Hku	involves: 129 * C57BL/6 * ICR	MGI:3796524
ht3	Ednra^tm2.1Hku/Ednra^tm3(Ednrb)Hku	involves: 129 * C57BL/6 * ICR	MGI:3796526
ht4	Ednra^tm2.1Hku/Ednra^tm4(Ednra)Hku	involves: 129 * C57BL/6 * ICR	MGI:3796528
ht5	Ednra^tm2.1Hku/Ednra^tm5Hku	involves: 129 * C57BL/6 * ICR	MGI:4867386

Genotype
MGI:3796522

hm1

• Allelic Composition: Ednra^tm2.1Hku/Ednra^tm2.1Hku
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Comparison of craniofacial skeletons among E15.5 Ednra^tm2.1Hku/Ednra^tm2.1Hku (A), wild-type (B) and Ednra^tm6(Edn1)Hku/Ednra⁺ (C) mice

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

craniofacial

absent Meckel's cartilage ( J:224515 )

• loss of Meckel's cartillage

abnormal temporal bone morphology ( J:224515 )

• duplicated ala temporalis

skeleton

absent Meckel's cartilage ( J:224515 )

• loss of Meckel's cartillage

abnormal temporal bone morphology ( J:224515 )

• duplicated ala temporalis

Genotype
MGI:3796524

ht2

• Allelic Composition: Ednra^tm1Hku/Ednra^tm2.1Hku
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

Genotype
MGI:3796526

ht3

• Allelic Composition: Ednra^tm2.1Hku/Ednra^{tm3(Ednrb)Hku}
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

• animals die at birth

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

growth/size/body

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

Genotype
MGI:3796528

ht4

• Allelic Composition: Ednra^tm2.1Hku/Ednra^{tm4(Ednra)Hku}
• Genetic Background: involves: 129 * C57BL/6 * ICR

craniofacial

craniofacial phenotype ( J:131382 )

N • craniofacial skeletal morphology is indistinguishable from wild-type; incisive alveolar bone in distal mandibular region is relatively well-developed

N • mice have relatively well-developed incisive alveolus

Genotype
MGI:4867386

ht5

• Allelic Composition: Ednra^tm2.1Hku/Ednra^tm5Hku
• Genetic Background: involves: 129 * C57BL/6 * ICR

cardiovascular system

abnormal heart morphology ( J:166932 )

• at E9.5, 40% of embryos have gourd-shaped hearts with disproportionate chamber sizes

abnormal heart development ( J:166932 )

• at E9.5 the number of proliferating cells is decreased in the compact and trabecular layers of the ventricular wall

abnormal heart ventricle morphology ( J:166932 )

• often have poorly developed ventricular walls at E9.5