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Targeted Allele Detail
Symbol: Prkar2btm2Gsm
Name: protein kinase, cAMP dependent regulatory, type II beta; targeted mutation 2, G Stanley McKnight
MGI ID: MGI:3773428
Synonyms: RIIbeta -, RIIbetaneolox, RIIbeta-neolox
Gene: Prkar2b  Location: Chr12:31958476-32061296 bp, - strand  Genetic Position: Chr12, 13.74 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:131039
Parent Cell Line:  REK3 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed neomycin cassette was inserted in the 5 prime untranslated region of the gene. Homozygous mice show no expression of the gene and are phenotypically identical to homozygote Prkar2btm1Gsm mice. (J:131039)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkar2b Mutation:  2 strains or lines available
Original:  J:131039 Czyzyk TA, et al., Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):276-81
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory