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Pafah2tm1Arai
Targeted Allele Detail
Summary
Symbol: Pafah2tm1Arai
Name: platelet-activating factor acetylhydrolase 2; targeted mutation 1, Hiroyuki Arai
MGI ID: MGI:3772686
Synonyms: Pafah2-
Gene: Pafah2  Location: Chr4:134123631-134154723 bp, + strand  Genetic Position: Chr4, 66.68 cM
Alliance: Pafah2tm1Arai page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130728
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 8 and 9 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on liver and kidney extracts. (J:130728)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pafah2 Mutation:  24 strains or lines available
References
Original:  J:130728 Kono N, et al., Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. J Biol Chem. 2008 Jan 18;283(3):1628-36
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory