Trim24^tm1Los
Targeted Allele Detail

Summary

• Symbol: Trim24^tm1Los
• Name: tripartite motif-containing 24; targeted mutation 1, Regine Losson
• MGI ID: MGI:3772050
• Synonyms: Trim24^L2
• Gene: Trim24 Location: Chr6:37847746-37943231 bp, + strand Genetic Position: Chr6, 17.07 cM, cytoband B1
• Alliance: Trim24^tm1Los page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130210
• Parent Cell Line: D4 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was floxed by introducing a loxP site upstream of the exon and inserting a loxP flanked PGK/TK neomycin cassette downstream of the exon. Chimeric mice were generated, crossed with a Cre-deleter strain, and offspring were selected that had the neomycin selection cassette removed but left exon 4 intact. Genotypes were confirmed by genomic PCR. (J:130210)

Tumor Data

List all tumor models in MMHCdb carrying Trim24^tm1Los

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim24 Mutation: 98 strains or lines available

References

• Original: J:130210 Khetchoumian K, et al., Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet. 2007 Dec;39(12):1500-6
• All: 2 reference(s)