Csnk2a1^tm1Dcs
Targeted Allele Detail

Summary

• Symbol: Csnk2a1^tm1Dcs
• Name: casein kinase 2, alpha 1 polypeptide; targeted mutation 1, David C Seldin
• MGI ID: MGI:3769802
• Synonyms: CK2alpha^-
• Gene: Csnk2a1 Location: Chr2:152068759-152123772 bp, + strand Genetic Position: Chr2, 74.83 cM
• Alliance: Csnk2a1^tm1Dcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129208
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 through exon 4 was replaced with a neo cassette deleting the critical lysine residue at amino acid position 68. This allele lacks the more abundant catalytic domain and authors state that it is a null allele. (J:129208)

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Csnk2a1 Mutation: 131 strains or lines available

References

• Original: J:129208 Lou DY, et al., The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development. Mol Cell Biol. 2008 Jan;28(1):131-9
• All: 5 reference(s)