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Sphk1tm1Npa
Targeted Allele Detail
Nomenclature
Symbol: Sphk1tm1Npa
Name: sphingosine kinase 1; targeted mutation 1, Novartis Pharma AG
MGI ID: MGI:3769485
Synonyms: Sphk1-
Gene: Sphk1  Location: Chr11:116530925-116536674 bp, + strand  Genetic Position: Chr11, 81.42 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129314
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 3 through 5 were replaced with a neo cassette. (J:129314)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sphk1 Mutation:  4 strains or lines available
References
Original:  J:129314 Zemann B, et al., Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood. 2006 Feb 15;107(4):1454-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory