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Sort1tm1Tew
Targeted Allele Detail
Nomenclature
Symbol: Sort1tm1Tew
Name: sortilin 1; targeted mutation 1, Thomas E Willnow
MGI ID: MGI:3767625
Synonyms: Sort1-
Gene: Sort1  Location: Chr3:108284082-108361511 bp, + strand  Genetic Position: Chr3, 46.9 cM, cytoband F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128451
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/SvEmcTer
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details126 bp of exon 14 and 202 bp of the subsequent intron were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis and immunohistochemistry. (J:128451)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sort1 Mutation:  8 strains or lines available
Notes
ES cell line = ICp4.
References
Original:  J:128451 Jansen P, et al., Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci. 2007 Nov;10(11):1449-57
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory