Fgf3tm1.1Sms
Targeted Allele Detail
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Symbol: |
Fgf3tm1.1Sms |
Name: |
fibroblast growth factor 3; targeted mutation 1.1, Suzanne L Mansour |
MGI ID: |
MGI:3767558 |
Synonyms: |
Fgf3delta2 |
Gene: |
Fgf3 Location: Chr7:144392349-144397085 bp, + strand Genetic Position: Chr7, 88.85 cM
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Alliance: |
Fgf3tm1.1Sms page
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Germline Transmission: |
Earliest citation of germline transmission:
J:128377
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Insertion of a targeting vector placed loxP sites on either side of exon 2. Cre recombination removed exon 2 and shifted downstream sequence out of frame with exon 1. The resulting transcript would putatively encode only the first 73 amino acids of the protein. This peptide is predicted to contain only the first 28 of 137 amino acids that comprise the core homology domain.
(J:128377)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fgf3 Mutation: |
16 strains or lines available
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Original: |
J:128377 Hatch EP, et al., Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007 Oct;134(20):3615-25 |
All: |
5 reference(s) |
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