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Targeted Allele Detail
Symbol: Fgf3tm1.1Sms
Name: fibroblast growth factor 3; targeted mutation 1.1, Suzanne L Mansour
MGI ID: MGI:3767558
Synonyms: Fgf3delta2
Gene: Fgf3  Location: Chr7:144838083-144844436 bp, + strand  Genetic Position: Chr7, 88.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:128377
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsInsertion of a targeting vector placed loxP sites on either side of exon 2. Cre recombination removed exon 2 and shifted downstream sequence out of frame with exon 1. The resulting transcript would putatively encode only the first 73 amino acids of the protein. This peptide is predicted to contain only the first 28 of 137 amino acids that comprise the core homology domain. (J:128377)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf3 Mutation:  12 strains or lines available
Original:  J:128377 Hatch EP, et al., Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007 Oct;134(20):3615-25
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory