Phenotypes associated with this allele

• Allele Symbol: Fgf3^tm1.1Sms
• Allele Name: targeted mutation 1.1, Suzanne L Mansour
• Allele ID: MGI:3767558
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf3^tm1.1Sms/Fgf3^tm1.1Sms	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ	MGI:4456410
hm2	Fgf3^tm1.1Sms/Fgf3^tm1.1Sms	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3769002
ht3	Fgf3^tm1Mrc/Fgf3^tm1.1Sms	involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * BALB/cJ	MGI:4456409
cx4	Fgf10^tm1.1Sms/Fgf10^tm1.1Sms Fgf3^tm1.1Sms/Fgf3^tm1.1Sms	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ	MGI:4456406

Genotype
MGI:4456410

hm1

• Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo development ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf3 null alleles

hearing/vestibular/ear

abnormal ear morphology ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf3 null alleles

Genotype
MGI:3769002

hm2

• Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

postnatal lethality ( J:128377 )

• at weaning, only 9% of heterozygous intercross offspring were homozygous mutant, indicating significant lethality associated with this allele

limbs/digits/tail

short tail ( J:128377 )

curly tail ( J:128377 )

hearing/vestibular/ear

dilated cochlea ( J:128377 )

• showed only rudimentary partitioning into distended cochlear chamber

abnormal scala vestibuli morphology ( J:128377 )

• showed only rudimentary partitioning into distended vestibular chamber

decreased cochlea coiling ( J:128377 )

• the swollen cochlear duct showed incomplete partition and poor coiling

absent common crus ( J:128377 )

absent posterior semicircular canal ( J:128377 )

• absence or severe truncation of the anterior and posterior semicircular canals in some

absent superior semicircular canal ( J:128377 )

• absence or severe truncation of the anterior and posterior semicircular canals in some

abnormal membranous labyrinth morphology ( J:128377 )

• all affected mutant ears had a distended membranous labyrinth

dilated scala media ( J:128377 )

abnormal utricle morphology ( J:128377 )

• fusion of utricle and saccule

abnormal vestibular saccule morphology ( J:128377 )

• fusion of utricle and saccule

absent endolymphatic sac ( J:128377 )

short endolymphatic duct ( J:128377 )

increased or absent threshold for auditory brainstem response ( J:128377 )

• significantly elevated ABR thresholds in one or both ears

behavior/neurological

head tilt ( J:128377 )

• a light head tilt were seen in mice showing significant ABR threshold increase only in one ear

circling ( J:128377 )

• in mice showing significant ABR threshold increase in bilateral ears

Genotype
MGI:4456409

ht3

• Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1.1Sms
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * BALB/cJ

embryo

abnormal embryo development ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf3 null alleles

hearing/vestibular/ear

abnormal ear morphology ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf3 null alleles

Genotype
MGI:4456406

cx4

• Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms; Fgf3^tm1.1Sms/Fgf3^tm1.1Sms
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ

hearing/vestibular/ear

absent otic vesicle ( J:160254 )

• mice exhibit small to absent otic vesicles compared with wild-type mice

small otic vesicle ( J:160254 )

• mice exhibit small to absent otic vesicles compared with wild-type mice

limbs/digits/tail

absent limbs ( J:160254 )

short tail ( J:160254 )