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Tg(Nes-cre/ERT2)KEisc
Transgene Detail
Nomenclature
Symbol: Tg(Nes-cre/ERT2)KEisc
Name: transgene insertion K, Amelia Eisch
MGI ID: MGI:3767432
Synonyms: Nestin-CreERT2, Tg(Nes-cre/ERT2)KJejo, Tg(Nes-cre/ESR1)KJejo, Tg(Nes-cre)KJejo
Transgene: Tg(Nes-cre/ERT2)KEisc  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe Nestin-cre/ERT2 transgene was designed with the rat nestin (Nes) promoter driving expression of a CreERT2 fusion gene (cre/ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). The transgene was microinjected into fertilized C57BL/6J oocytes, and line K was established. (J:117032, J:141562)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nes     Summary of all recombinase alleles driven by Nes.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:117032 Battiste J, et al., Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development. 2007 Jan;134(2):285-93
All:  103 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory