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Myt1tm1Ggu
Targeted Allele Detail
Nomenclature
Symbol: Myt1tm1Ggu
Name: myelin transcription factor 1; targeted mutation 1, Guoqiang Gu
MGI ID: MGI:3765054
Synonyms: Myt1f
Gene: Myt1  Location: Chr2:181763332-181827775 bp, + strand  Genetic Position: Chr2, 103.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127471
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA FRT flanked pGK-Neo cassette and a loxP site was inserted upstream of exon 9 (or exon 3 when the short alternative transcript is being produced) and a third loxP site was inserted downstream of the exon. Mice were crossed with a Flpe deleter strain to remove the selection cassette, leaving the targeted exon flanked by loxP sites with one FRT site remaining upstream of the targeted exon but downstream of the first loxP site. (J:127471)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myt1 Mutation:  34 strains or lines available
References
Original:  J:127471 Wang S, et al., Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory