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Ptger3tm1Csml
Targeted Allele Detail
Nomenclature
Symbol: Ptger3tm1Csml
Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1, Clifford B Saper
MGI ID: MGI:3764893
Synonyms: ptger3flox
Gene: Ptger3  Location: Chr3:157566816-157644758 bp, + strand  Genetic Position: Chr3, 81.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127396
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was introduced 70 bp upstream of the translation initiation site and a loxP-frt-Neo/KanR-frt cassette was inserted 408 bp downstream of exon 1. The selectable markers were removed by flp-mediated recombination using transient flp expression. Normal expression patterns in the brain were confirmed by in situ hybridization. (J:127396)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptger3 Mutation:  8 strains or lines available
References
Original:  J:127396 Lazarus M, et al., EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci. 2007 Sep;10(9):1131-3
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory