Evx2/Hoxd13^tm4(cre)Ddu
Targeted Allele Detail

Summary

• Symbol: Evx2/Hoxd13^tm4(cre)Ddu
• Name: homeobox D13; targeted mutation 4, Denis Duboule
• MGI ID: MGI:3762125
• Synonyms: CreDel0, Hoxd11/Cre, HoxD^d11Cre, HoxD^d11CreDel0
• Gene: Hoxd13 Location: Chr2:74498654-74501943 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Evx2/Hoxd13^tm4(cre)Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82530
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Evx2/Hoxd13^tm4(cre)Ddu expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxd11 (MGI:96203)

• Mutation details: A mouse Hoxd11 trangene construct was modified by in-frame insertion of the Cre coding sequence, followed by the SV40 polyadenylation signal, at the start codon in exon 1 so that Cre recombinase is expressed under control of the Hoxd11 regulatory elements, but without any residues derived from Hoxd11. Homology arms were added to target integration to a site between Hoxd13 and Evx2, at the 5' extremity of the cluster. (J:82530)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxd11 (mouse) Summary of all recombinase alleles driven by Hoxd11. Alliance mouse Hoxd11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd13 Mutation: 24 strains or lines available

References

• Original: J:82530 Herault Y, et al., A nested deletion approach to generate Cre deleter mice with progressive Hox profiles. Int J Dev Biol. 2002;46(1 Spec No):185-91
• All: 1 reference(s)