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Targeted Allele Detail
Symbol: Cyldtm1Awai
Name: cylindromatosis (turban tumor syndrome); targeted mutation 1, Ari Waisman
MGI ID: MGI:3761621
Synonyms: CYLDF
Gene: Cyld  Location: Chr8:88697028-88751945 bp, + strand  Genetic Position: Chr8, 43.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:126113
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo was insert upstream of exoon 7 and an additional loxP site downstream of exon 7. The neo cassette was subsequently removed by cre-mediated recombination using a transient transfection of a cre-expressing plasmid. Insertion was confirmed by Southern blot. (J:126113)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyld Mutation:  13 strains or lines available
Original:  J:126113 Hovelmeyer N, et al., Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. J Exp Med. 2007 Oct 29;204(11):2615-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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