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Chn1tm1.1Ito
Targeted Allele Detail
Nomenclature
Symbol: Chn1tm1.1Ito
Name: chimerin 1; targeted mutation 1.1 Shigeyoshi Itohara
MGI ID: MGI:3760002
Synonyms: alpha-Chn KO
Gene: Chn1  Location: Chr2:73610660-73775346 bp, - strand  Genetic Position: Chr2, 43.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125703
Parent Cell Line:  MS12 (ES Cell)
Strain of Origin:  C57BL/6NSlc
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsLoxP-flanked genomic sequences containing exons 9 and 10 were deleted by cre-mediated recombination. A single loxP site remains in place of a KpnI-HindIII fragment of this gene. Western blot analyses using an alpha2-chimerin-specific antibody confirmed no expression of the encoded protein in homozygous mice. (J:125703)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chn1 Mutation:  24 strains or lines available
References
Original:  J:125703 Iwasato T, et al., Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell. 2007 Aug 24;130(4):742-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory