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Robo2tm1.1Rilm
Targeted Allele Detail
Nomenclature
Symbol: Robo2tm1.1Rilm
Name: roundabout guidance receptor 2; targeted mutation 1.1, Richard Maas
MGI ID: MGI:3759448
Synonyms: Robo2del5
Gene: Robo2  Location: Chr16:73891839-74411825 bp, - strand  Genetic Position: Chr16, 42.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125214
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 5 was removed by cre-mediated recombination. A marked reduction in transcript size and quantity was confirmed by RT-PCR and in situ hybridization. Authors state that this allele is a null allele. (J:125214)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Robo2 Mutation:  2 strains or lines available
References
Original:  J:125214 Lu W, et al., Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet. 2007 Apr;80(4):616-32
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory