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Tg(Camk2a-cre/ERT2)2Gsc
Transgene Detail
Summary
Symbol: Tg(Camk2a-cre/ERT2)2Gsc
Name: transgene insertion 2, Gunther Schutz
MGI ID: MGI:3759305
Synonyms: CaMKCreERT2, Tg(Camk2a-cre/ESR1)2Gsc
Transgene: Tg(Camk2a-cre/ERT2)2Gsc  Location: unknown  
Alliance: Tg(Camk2a-cre/ERT2)2Gsc page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Camk2a-cre/ERT2)2Gsc expression driven by 1 gene
 
Mutation detailsThe Camk2a promoter was used to drive expression of a cre and human estrogen receptor fusion (cre/ESR1). Expression is inducible by tamoxifen and localizes to the neurons of the adult forebrain. (J:125230)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Camk2a (species not specified)
Summary of all recombinase alleles driven by Camk2a.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Three lines were created (lines 1, 2 and 3) with 1, 2 and 4 copy numbers of the transgene, respectively. Line 2 was choosen as the representative line because while copy number affects the level of expression similar phenotypes are produced and the majority of the reporting in J:125230 focuses on line 2.
References
Original:  J:125230 Erdmann G, et al., Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci. 2007;8:63
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory