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Tg(dlx5a-cre)1Mekk
Transgene Detail
Nomenclature
Symbol: Tg(dlx5a-cre)1Mekk
Name: transgene insertion 1, Marc Ekker
MGI ID: MGI:3758328
Synonyms: Dlx5/6-Cre, Dlx5/6i-Cre, line 8561, Tg(dlx6a-cre)1Mars, Tg(dlx6a-cre)1Mekk
Transgene: Tg(dlx5a-cre)1Mekk  Location: unknown  
Transgene
origin
Strain of Origin:  CD-1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cre gene was placed under the control of the I56i and I56ii enhancer elements of zebrafish dlx5a and a 3.5kb genomic DNA fragment flanking the 5' region of the zebrafish dlx6a open reading frame and containing the 5'UTR. The dlx6a flanking region on its own cannot produce tissue specific expression but increases the activity of the enhancers to produce expression that recapitulate endogenous Dlx5 expression. Tissue specific expression was confirmed by test crosses to reporter mice strains, including Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(ACTB-Bgeo/GFP)21Lbe and Gt(ROSA)26Sortm1Sor. (J:122066)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: dlx5a     Summary of all recombinase alleles driven by dlx5a.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:122066 Monory K, et al., The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 2006 Aug 17;51(4):455-66
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/09/2018
MGI 6.11
The Jackson Laboratory