Tg(dlx5a-cre)1Mekk
Transgene Detail
|
Symbol: |
Tg(dlx5a-cre)1Mekk |
Name: |
transgene insertion 1, Marc Ekker |
MGI ID: |
MGI:3758328 |
Synonyms: |
Dlx5/6-Cre, Dlx5/6i-Cre, line 8561, Tg(dlx6a-cre)1Mars, Tg(dlx6a-cre)1Mekk |
Transgene: |
Tg(dlx5a-cre)1Mekk Location: unknown
|
|
|
Transgene Type: |
|
Transgenic (Recombinase) |
Mutation: |
|
Insertion
|
|
|
Mutation details: A cre gene was placed under the control of the I56i and I56ii enhancer elements of zebrafish dlx5a and a 3.5kb genomic DNA fragment flanking the 5' region of the zebrafish dlx6a open reading frame and containing the 5'UTR. The dlx6a flanking region on its own cannot produce tissue specific expression but increases the activity of the enhancers to produce expression that recapitulate endogenous Dlx5 expression. Tissue specific expression was confirmed by test crosses to reporter mice strains, including Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(ACTB-Bgeo/GFP)21Lbe and Gt(ROSA)26Sortm1Sor.
(J:122066)
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
Driver:
|
dlx5a
Summary of all recombinase alleles
driven by dlx5a.
|
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:122066 Monory K, et al., The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 2006 Aug 17;51(4):455-66 |
All: |
99 reference(s) |
|