Tg(dlx5a-cre)1Mekk
Transgene Detail

Nomenclature

• Symbol: Tg(dlx5a-cre)1Mekk
• Name: transgene insertion 1, Marc Ekker
• MGI ID: MGI:3758328
• Synonyms: Dlx5/6-Cre, Dlx5/6i-Cre, line 8561, Tg(dlx6a-cre)1Mars, Tg(dlx6a-cre)1Mekk
• Transgene: Tg(dlx5a-cre)1Mekk Location: unknown

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Mutation details: A cre gene was placed under the control of the I56i and I56ii enhancer elements of zebrafish dlx5a and a 3.5kb genomic DNA fragment flanking the 5' region of the zebrafish dlx6a open reading frame and containing the 5'UTR. The dlx6a flanking region on its own cannot produce tissue specific expression but increases the activity of the enhancers to produce expression that recapitulate endogenous Dlx5 expression. Tissue specific expression was confirmed by test crosses to reporter mice strains, including Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(ACTB-Bgeo/GFP)21Lbe and Gt(ROSA)26Sor^tm1Sor. (J:122066)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	dlx5a     Summary of all recombinase alleles driven by dlx5a.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:122066 Monory K, et al., The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 2006 Aug 17;51(4):455-66
• All: 61 reference(s)