Igh^tm2Hws
Targeted Allele Detail

Summary

• Symbol: Igh^tm2Hws
• Name: immunoglobulin heavy chain complex; targeted mutation 2, Harry W Schroeder Jr
• MGI ID: MGI:3757670
• Synonyms: iD
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124421
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted
• Mutations: Deletion, Insertion
• Igh^tm2Hws involves 1 genes/genome features (Igh) View all
• Mutation details: The central portion of the DFL16.1 segment was replaced with the inverted coding sequence of the DSP2.2 segment and a downstream loxP neo cassette. This vector was used in targeting ES cells from Igh^tm1.1Lnit that had the DQ52 segment replaced with a loxP site. (J:124421)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:124421 Ippolito GC, et al., Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. J Exp Med. 2006 Jun 12;203(6):1567-78
• All: 1 reference(s)