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Targeted Allele Detail
Symbol: Nod2tm1Jhgt
Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Jean-Pierre Hugot
MGI ID: MGI:3722087
Synonyms: Card15/Nod2-, Nod2-
Gene: Nod2  Location: Chr8:88647315-88688474 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:124575
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first coding exon carrying the majority of the sequence encoding the CARD domains, including the start codon, was replaced with an EGFP cassette. A PGK-hygromycin cassette included in the vector was removed via cre mediated recombination. (J:124575)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:  6 strains or lines available
Original:  J:124575 Barreau F, et al., CARD15/NOD2 is required for Peyer's patches homeostasis in mice. PLoS One. 2007;2(6):e523
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory