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Arntltm1Weit
Targeted Allele Detail
Nomenclature
Symbol: Arntltm1Weit
Name: aryl hydrocarbon receptor nuclear translocator-like; targeted mutation 1, Charles Weitz
MGI ID: MGI:3720808
Synonyms: Bmal1lox, Bmalf, conditional Bmal
Gene: Arntl  Location: Chr7:113207465-113314126 bp, + strand  Genetic Position: Chr7, 59.17 cM, cytoband F2-F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124157
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsUsing homologous recombination in a bacterial artificial chromosome (BAC, clone RPCI23-331K23), an FRT-flanked neo cassette (followed by a loxP site) was inserted immediately downstream of exon 8 of the targeted gene. An additional loxP site was added upstream of exon 8 when the targeting vector was excised from the BAC. Correctly targeted ES cells were injected into blastocysts and chimeric mice were bred to Flpe-expressing mice to excise the neo cassette. (J:124157)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arntl Mutation:  123 strains or lines available
References
Original:  J:124157 Storch KF, et al., Intrinsic circadian clock of the Mammalian retina: importance for retinal processing of visual information. Cell. 2007 Aug 24;130(4):730-41
All:  73 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory