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Catsper3tm1Wyan
Targeted Allele Detail
Nomenclature
Symbol: Catsper3tm1Wyan
Name: cation channel, sperm associated 3; targeted mutation 1, Wei Yan
MGI ID: MGI:3720684
Synonyms: Catsper3-
Gene: Catsper3  Location: Chr13:55784568-55808998 bp, + strand  Genetic Position: Chr13, 30.06 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124054
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 and 5 were replaced by a pgk-HPRT cassette in reverse orientation. These exons encode amino acids 152-257, which contain the pore forming region located between the fifth and sixth transmembrane domains of the gene. Northern blot confirmed that the transcript was truncated. (J:124054)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Catsper3 Mutation:  13 strains or lines available
References
Original:  J:124054 Jin J, et al., Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Biol Reprod. 2007 Jul;77(1):37-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory