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Targeted Allele Detail
Symbol: Esrrbtm1.2Nat
Name: estrogen related receptor, beta; targeted mutation 1.2, Jeremy Nathans
MGI ID: MGI:3720482
Synonyms: Nr3b2-
Gene: Esrrb  Location: Chr12:86361117-86521628 bp, + strand  Genetic Position: Chr12, 40.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:124941
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsBreeding of Nr3b2tm1.1Nat mice to Cre-expressing mice results in deletion of the exon containing the initiator methionine codon and encoding the N-terminal 132 amino acids (including part of the DNA-binding domain) in the cre-expressing tissue(s). (J:124941)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esrrb Mutation:  236 strains or lines available
Original:  J:124941 Chen J, et al., Estrogen-Related Receptor beta/NR3B2 Controls Epithelial Cell Fate and Endolymph Production by the Stria Vascularis. Dev Cell. 2007 Sep;13(3):325-37
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory