Siglecg^tm1Lnit
Targeted Allele Detail

Summary

• Symbol: Siglecg^tm1Lnit
• Name: sialic acid binding Ig-like lectin G; targeted mutation 1, Lars Nitschke
• MGI ID: MGI:3718495
• Synonyms: Siglecg^-
• Gene: Siglecg Location: Chr7:43057623-43067773 bp, + strand Genetic Position: Chr7, 28.25 cM
• Alliance: Siglecg^tm1Lnit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123353
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Parts of exons 2 and 3, encoding the putative sialic acid-binding domain were replaced with a floxed PGK-neo cassette. RT-PCR confirmed absence of mRNA in mutant splenocytes. (J:123353)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siglecg Mutation: 41 strains or lines available

References

• Original: J:123353 Hoffmann A, et al., Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population. Nat Immunol. 2007 Jul;8(7):695-704
• All: 10 reference(s)