Tg(KRT5-CCND1)1Sprd
Transgene Detail

Summary

• Symbol: Tg(KRT5-CCND1)1Sprd
• Name: transgene insertion 1, Science Park-Research Division
• MGI ID: MGI:3717245
• Synonyms: K5-D1, K5D1b, Tg(Krt36-Ccnd1)1Sprd
• Transgene: Tg(KRT5-CCND1)1Sprd Location: unknown
• Alliance: Tg(KRT5-CCND1)1Sprd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-CCND1)1Sprd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CCND1 (595)

  Ccnd1

  (MGI:88313)

• Tg(KRT5-CCND1)1Sprd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: This transgene expresses the human cyclin D1b cDNA under the control of the bovine keratin 5 promoter. Expression of the protein was detected in tail sections; additional immunohistochemical analysis detected expression in tissues that bear stratified squamous epithelia including skin, tongue, esophagus, thymus, cervix and vagina. (J:34315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:34315 Robles AI, et al., Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7634-8
• All: 4 reference(s)