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Targeted Allele Detail
Symbol: Hs6st1tm1Kkm
Name: heparan sulfate 6-O-sulfotransferase 1; tageted mutation 1, Koji Kimata
MGI ID: MGI:3715259
Gene: Hs6st1  Location: Chr1:36068400-36106446 bp, + strand  Genetic Position: Chr1, 15.15 cM, cytoband B
Hs6st1tm1Kkm/Hs6st1tm1Kkm mice exhibit growth retardation and abnormal eye, phalanges, and tarsus morphology

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:122656
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 0.7kb fragment encoding the critical 3'-phosphoadenosine 5'-phosphosulfate binding site was replaced with a neo cassette. The absence of transcript was confirmed by northen blot. (J:122656)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hs6st1 Mutation:  12 strains or lines available
Original:  J:122656 Habuchi H, et al., Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007 May 25;282(21):15578-88
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory