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Pggt1btm1Mbrg
Targeted Allele Detail
Nomenclature
Symbol: Pggt1btm1Mbrg
Name: protein geranylgeranyltransferase type I, beta subunit; targeted mutation 1, Martin O Bergo
MGI ID: MGI:3713756
Synonyms: Pggt1bfl
Gene: Pggt1b  Location: Chr18:46235351-46280993 bp, - strand  Genetic Position: Chr18, 24.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122107
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert loxP sites to flank exon 7, which is critical for enzymatic activity. (J:122107)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pggt1b Mutation:  10 strains or lines available
References
Original:  J:122107 Sjogren AK, et al., GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest. 2007 May;117(5):1294-304
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory