About   Help   FAQ
Targeted Allele Detail
Symbol: Adam17tm1.1Bbl
Name: a disintegrin and metallopeptidase domain 17; tareted mutation 1.1, Carl P Blobel
MGI ID: MGI:3713366
Synonyms: Adam17-, Tace-
Gene: Adam17  Location: Chr12:21323509-21373632 bp, - strand  Genetic Position: Chr12, 8.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:139846
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsAdam17tm1Bbl heterozygotes were mated with Tg(EIIa-cre)C5379Lmgd to remove exon 2 of the gene locus from the germline. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of embryonic fibroblasts. (J:139846)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam17 Mutation:  11 strains or lines available
Original:  J:139846 Horiuchi K, et al., Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol. 2007 Sep 1;179(5):2686-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory