Adam17tm1.1Bbl
Targeted Allele Detail
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Symbol: |
Adam17tm1.1Bbl |
Name: |
a disintegrin and metallopeptidase domain 17; targeted mutation 1.1, Carl P Blobel |
MGI ID: |
MGI:3713366 |
Synonyms: |
A17-, Adam17-, Tace- |
Gene: |
Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
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Alliance: |
Adam17tm1.1Bbl page
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Failure of eyelid closure, enlarged aortic, pulmonic, and tricuspid heart valves, and enlarged zone of hypertrophic chondrocytes in growth plates of Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi Rhbdf2tm1Mak/Rhbdf2tm1Mak (iR1/2-/-) and Adam17tm1.1Bbl/Adam17tm1.1Bbl mice.
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:139846
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Adam17tm1Bbl heterozygotes were mated with Tg(EIIa-cre)C5379Lmgd to remove floxed exon 2 of the gene locus from the germline. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of embryonic fibroblasts.
(J:139846)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Adam17 Mutation: |
62 strains or lines available
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Original: |
J:139846 Horiuchi K, et al., Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol. 2007 Sep 1;179(5):2686-9 |
All: |
11 reference(s) |
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