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Targeted Allele Detail
Symbol: Adam17tm1Bbl
Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1, Carl P Blobel
MGI ID: MGI:3713365
Synonyms: Taceflox
Gene: Adam17  Location: Chr12:21323509-21373632 bp, - strand  Genetic Position: Chr12, 8.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:139846
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site, and a frt-flanked neomycin resistance cassette was inserted upstream of exon 2, and another loxP site and an EcoRI restriction site was inserted 1 kb downstream of exon 2. Correct targeting was confirmed by Southern blotting and genomic PCR. (J:139846)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam17 Mutation:  40 strains or lines available
Original:  J:139846 Horiuchi K, et al., Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol. 2007 Sep 1;179(5):2686-9
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory