Irak4^tm1Gram
Targeted Allele Detail

Summary

• Symbol: Irak4^tm1Gram
• Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1, Hermann Gram
• MGI ID: MGI:3712883
• Synonyms: Irak4 KD
• Gene: Irak4 Location: Chr15:94441495-94466198 bp, + strand Genetic Position: Chr15, 48.55 cM, cytoband F1
• Alliance: Irak4^tm1Gram page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121912
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The KK213AA mutation was inserted into exon 5. A floxed neo included in the vector was removed via cre mediated recombination. This mutation abolishes the kinase activity without affecting other protein features. (J:121912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irak4 Mutation: 30 strains or lines available

References

• Original: J:121912 Koziczak-Holbro M, et al., IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression. J Biol Chem. 2007 May 4;282(18):13552-60
• All: 3 reference(s)