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Targeted Allele Detail
Symbol: Cxcl9tm1Jmf
Name: chemokine (C-X-C motif) ligand 9; targeted mutation 1, Joshua M Farber
MGI ID: MGI:3712351
Synonyms: Cxcl9-, Mig-
Gene: Cxcl9  Location: Chr5:92321347-92328079 bp, - strand  Genetic Position: Chr5, 46.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:121818
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neomycin resistance gene resulted in the deletion of 1458 bp of the locus, including 104 bp of exon 2 and 1354 bp of intron 2. The predicted mRNA consists of the signal peptide followed by 7 amino-terminal amino acids and a stop codon. Western blot confirmed absence of protein in mutant liver microsomes. (J:121818)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcl9 Mutation:  7 strains or lines available
Original:  J:121818 Park MK, et al., The CXC chemokine murine monokine induced by IFN-gamma (CXC chemokine ligand 9) is made by APCs, targets lymphocytes including activated B cells, and supports antibody responses to a bacterial pathogen in vivo. J Immunol. 2002 Aug 1;169(3):1433-43
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory