Runx1tm1(cre/Esr1*)Ims
Targeted Allele Detail
|
Symbol: |
Runx1tm1(cre/Esr1*)Ims |
Name: |
runt related transcription factor 1; targeted mutation 1, Igor M Samokhvalov |
MGI ID: |
MGI:3711451 |
Synonyms: |
Runx1Cre, Runx1CreER, Runx1MER-Cre-MER, Runx1tm1(cre)Ims |
Gene: |
Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
|
Alliance: |
Runx1tm1(cre/Esr1*)Ims page
|
|
|
Allele Type: |
|
Targeted (Hypomorph, Inducible, Recombinase) |
Inducer: |
|
tamoxifen |
Mutation: |
|
Insertion
|
|
|
Runx1tm1(cre/Esr1*)Ims expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Runx1 (MGI:99852) |
|
|
|
|
Mutation details: A targeting vector was designed to insert a tamoxifen-inducible cre recombinase flanked by two mutated estrogen receptors and a floxed neo into the Runx1 gene downstream of the proximal (P2) promoter. The neo was subsequently removed via exogenous cre expression. A subsequent reference states that the allele was determined to be hypomorphic, with homozygotes developing to term but dying in the first postnatal day.
(J:121435, J:182232)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
Runx1
(mouse)
|
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Runx1 Mutation: |
35 strains or lines available
|
|
Original: |
J:121435 Samokhvalov IM, et al., Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature. 2007 Apr 26;446(7139):1056-61 |
All: |
16 reference(s) |
|