All Phenotypes Runx1<tm1(cre/Esr1*)Ims> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Runx1^{tm1(cre/Esr1*)Ims}
targeted mutation 1, Igor M Samokhvalov
MGI:3711451

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Runx1^{tm1(cre/Esr1)Ims}/Runx1^{tm1(cre/Esr1)Ims}	involves: C57BL/6 * CBA	MGI:5316036
ht2	Runx1^{tm1(cre/Esr1*)Ims}/Runx1⁺	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)	MGI:3712087
cn3	Mapt^tm2Arbr/? Runx1^tm3Spe/Runx1^{tm1(cre/Esr1*)Ims}	involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj	MGI:5702485
cn4	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? Runx1^{tm1(cre/Esr1*)Ims}/?	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	MGI:5702484

Allelic Composition	Runx1^{tm1(cre/Esr1)Ims}/Runx1^{tm1(cre/Esr1)Ims}
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^{tm1(cre/Esr1*)Ims} mutation (0 available); any Runx1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:182232 )

• pups develop successfully to term, but are unable to feed and die during the first day postpartum

Allelic Composition	Runx1^{tm1(cre/Esr1*)Ims}/Runx1⁺
Genetic Background	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^{tm1(cre/Esr1*)Ims} mutation (0 available); any Runx1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:121435 )

N	• heterozygotes appear normal, with no observable defects in hematopoietic system development

Allelic Composition	Mapt^tm2Arbr/? Runx1^tm3Spe/Runx1^{tm1(cre/Esr1*)Ims}
Genetic Background	involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Runx1^{tm1(cre/Esr1*)Ims} mutation (0 available); any Runx1 mutation (35 available)
Runx1^tm3Spe mutation (0 available); any Runx1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal mechanoreceptor morphology ( J:226826 )

• few or no tyrosine hydroxylase C-low threshold mechanoreceptors (C-LTMRs) are observed in P21 mice following tamoxifen administration at P2

• decrease in the number of longitudinal lanceolate endings (characteristic of C-LTMRs) in back hairy skin of P21 mice

Allelic Composition	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? Runx1^{tm1(cre/Esr1*)Ims}/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm2.1Ddg mutation (1 available); any Cbfb mutation (36 available)
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Runx1^{tm1(cre/Esr1*)Ims} mutation (0 available); any Runx1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal mechanoreceptor morphology ( J:226826 )

• few or no tyrosine hydroxylase C-low threshold mechanoreceptors (C-LTMRs) are observed in P21 mice following tamoxifen administration at P2

• decrease in the number of longitudinal lanceolate endings (characteristic of C-LTMRs) in back hairy skin of P21 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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