About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Braftm1Wds
Targeted Allele Detail
Nomenclature
Symbol: Braftm1Wds
Name: Braf transforming gene; targeted mutation 1, William D Snider
MGI ID: MGI:3711006
Synonyms: Brafexon3f, Braff
Gene: Braf  Location: Chr6:39603237-39725463 bp, - strand  Genetic Position: Chr6, 18.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121660
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank exon 3 according to nomenclature in J:29234. An FRT-flanked neomycin resistance cassette was removed prior to ES cell injection. Deletion of exon 3 would cause a reading frame shift and introduce a translational stop codon at position 132, truncating the RBD, CRD and kinase domains. (J:121660)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Braf Mutation:  13 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Neurocardiofaciocutaneous syndromes ( J:144862)
References
Original:  J:121660 Zhong J, et al., Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci. 2007 May;10(5):598-607
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/05/2019
MGI 6.14
The Jackson Laboratory