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Tg(CD19-BTK*K430R)XK24Rwhe
Transgene Detail
Nomenclature
Symbol: Tg(CD19-BTK*K430R)XK24Rwhe
Name: transgene insertion XK24, Rudolf Hendriks
MGI ID: MGI:3709262
Synonyms: Btk-K430R, CD19-hBtkK430R
Transgene: Tg(CD19-BTK*K430R)XK24Rwhe  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA composite fragment composed of 400bp from exons 1-3 of a BTK cDNA as well as 27kb genomic fragment containing exons 3-19 of BTK was placed under the control of the promoter region of human CD19. A K430R mutation was introduced into this construct by double stranded site-directed mutagenesis. (J:120989)
Phenotypes
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:120989 Middendorp S, et al., Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity. J Immunol. 2003 Dec 1;171(11):5988-96
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory