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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CD19-BTK*K430R)XK24Rwhe
transgene insertion XK24, Rudolf Hendriks
MGI:3709262
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/? 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB MGI:3709379
cx2
 		Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/? 		involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:3709381


Genotype
MGI:3709379
cx1
Allelic
Composition		 Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (76 available)
Btktm1Gsv mutation (0 available); any Btk mutation (22 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:94768 )
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
decreased IgG3 level ( J:94768 )
• IgG3 levels remain severely reduced
decreased IgM level ( J:94768 )
• improved or restored

neoplasm
neoplasm ( J:94768 )
N
• tumor suppressor function is restored

hematopoietic system
abnormal B cell differentiation ( J:94768 )
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
decreased IgG3 level ( J:94768 )
• IgG3 levels remain severely reduced
decreased IgM level ( J:94768 )
• improved or restored




Genotype
MGI:3709381
cx2
Allelic
Composition		 Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Gsv mutation (0 available); any Btk mutation (22 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:94768 )
N
• calcium signaling of splenic B cells is restored
decreased B cell apoptosis ( J:120989 )
• B cell apoptosis is reduced compared to similar mice lacking the transgene
decreased B cell number ( J:120989 )
• restored B220+ cell numbers peripherally
absent B-1a cells ( J:120989 )
• deficiency of CD5+ B cells in the peritoneum remains
abnormal pre-B cell morphology ( J:120989 )
• differentiation is partially restored
decreased immunoglobulin level ( J:120989 )
• decreased lambda light chain usage

hematopoietic system
decreased B cell apoptosis ( J:120989 )
• B cell apoptosis is reduced compared to similar mice lacking the transgene
decreased B cell number ( J:120989 )
• restored B220+ cell numbers peripherally
absent B-1a cells ( J:120989 )
• deficiency of CD5+ B cells in the peritoneum remains
abnormal pre-B cell morphology ( J:120989 )
• differentiation is partially restored
decreased immunoglobulin level ( J:120989 )
• decreased lambda light chain usage

cellular
decreased B cell apoptosis ( J:120989 )
• B cell apoptosis is reduced compared to similar mice lacking the transgene




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory